Multicolor Licklider Transmission Protocol: An LTP Version for Future Interplanetary Links

The Licklider Transport Protocol (LTP) is the "convergence layer" of choice in Interplanetary networks based on Delay-/Disruption-Tolerant architecture. It was designed for long-delay scheduled-intermittent links, offering either a reliable or an unreliable service, with "red" and "green" parts, respectively. The aim of this article is to present multicolor LTP, an LTP version consisting in a series of enhancements of which the most significant are the use of monochrome sessions, the introduction of an additional orange color offering a "notified" service, and the definition of default link colors. After a thorough examination of basic LTP mechanisms for all color variants, this article discusses two scenarios where orange seems particularly appealing: video streaming and optical interplanetary links. Numerical results offer further insight into the complex LTP mechanisms and also highlight the difference between LTP retransmissions and bundle protocol retransmissions, the latter benefitting from routing reprocessing. Multicolor LTP has already been implemented as an interplanetary overlay network (ION) plug-in and its enhancements have been proposed to Consultative Committee for Space Data Systems Space Internetworking Services Delay-/Disruption-Tolerant Networking working group for a possible inclusion in the next version of LTP specifications (LTPv2)

Research challenges in nanosatellite-DTN networks

Current approaches based on classical satellite communications, aimed at bringing Internet connectivity to remote and underdeveloped areas, are too expensive and impractical. Nanosatellites architectures with DTN protocol have been proposed as a cost-effective solution to extend the network access in rural and remote areas. In order to guarantee a good service and a large coverage in rural areas, it is necessary to deploy a good number of nanosatellites; consequentially, for reliability and load balancing purposes, is also needed a large number of ground stations (or hot spots) connected on the Internet. During a data connection, a server on the Internet that wants to reply to the user on rural area, has many hot spot alternatives to whom it can deliver data. Different hot spots can send data to final destination with different delivery delay depending on the number, position and buffer occupancy of satellites with which it comes into contact. The problem of choosing the optimal hot spot becomes important because a wrong choice could lead a high delivery delay

Transport layer protocols and architectures for satellite networks

Designing efficient transmission mechanisms for advanced satellite networks is a demanding task, requiring the definition and the implementation of protocols and architectures well suited to this challenging environment. In particular, transport protocols performance over satellite networks is impaired by the characteristics of the satellite radio link, specifically by the long propagation delay and the possible presence of segment losses due to physical channel errors. The level of impact on performance depends upon the link design (type of constellation, link margin, coding and modulation) and operational conditions (link obstructions, terminal mobility, weather conditions, etc.). To address these critical aspects a number of possible solutions have been presented in the literature, ranging from limited modifications of standard protocols (e.g. TCP, transmission control protocol) to completely alternative protocol and network architectures. However, despite the great number of different proposals (or perhaps also because of it), the general framework appears quite fragmented and there is a compelling need of an integration of the research competences and efforts. This is actually the intent of the transport protocols research line within the European SatNEx (Satellite Network of Excellence) project. Stemming from the authors' work on this project, this paper aims to provide the reader with an updated overview of all the possible approaches that can be pursued to overcome the limitations of current transport protocols and architectures, when applied to satellite communications. In the paper the possible solutions are classified in the following categories: optimization of TCP interactions with lower layers, TCP enhancements, performance enhancement proxies (PEP) and delay tolerant networks (DTN). Advantages and disadvantages of the different approaches, as well as their interactions, are investigated and discussed, taking into account performance improvement, complexity, and compliance to the standard semantics. From this analysis, it emerges that DTN architectures could integrate some of the most efficient solutions from the other categories, by inserting them in a new rigorous framework. These innovative architectures therefore may represent a promising solution for solving some of the important problems posed at the transport layer by satellite networks, at least in a medium-to-long-term perspective. Copyright (c) 2006 John Wiley & Sons, Ltd

Gender-Dependent Specificities in Cutaneous Melanoma Predisposition, Risk Factors, Somatic Mutations, Prognostic and Predictive Factors: A Systematic Review.

Over the last decades, the incidence of melanoma has been steadily growing, with 4.2% of the population worldwide affected by cutaneous melanoma (CM) in 2020 and with a higher incidence and mortality in men than in women. We investigated both the risk factors for CM development and the prognostic and predictive factors for survival, stratifying for both sex and gender. We conducted a systematic review of studies indexed in PUB-MED, EMBASE, and Scopus until 4 February 2021. We included reviews, meta-analyses, and pooled analyses investigating differences between women and men in CM risk factors and in prognostic and predictive factors for CM survival. Twenty-four studies were included, and relevant data extracted. Of these, 13 studies concerned potential risk factors, six concerned predictive factors, and five addressed prognostic factors of melanoma. The systematic review revealed no significant differences in genetic predisposition to CM between males and females, while there appear to be several gender disparities regarding CM risk factors, partly attributable to different lifestyles and behavioral habits between men and women. There is currently no clear evidence of whether the mutational landscapes of CM differ by sex/gender. Prognosis is justified by a complex combination of phenotypes and immune functions, while reported differences between genders in predicting the effectiveness of new treatments are inconsistent. Overall, the results emerging from the literature reveal the importance of considering the sex/gender variable in all studies and pave the way for including it towards precision medicine. Men and women differ genetically, biologically, and by social construct. Our systematic review shows that, although fundamental, the variable sex/gender is not among the ones collected and analyzed

QoSatAr: a cross-layer architecture for E2E QoS provisioning over DVB-S2 broadband satellite systems

This article presents QoSatAr, a cross-layer architecture developed to provide end-to-end quality of service (QoS) guarantees for Internet protocol (IP) traffic over the Digital Video Broadcasting-Second generation (DVB-S2) satellite systems. The architecture design is based on a cross-layer optimization between the physical layer and the network layer to provide QoS provisioning based on the bandwidth availability present in the DVB-S2 satellite channel. Our design is developed at the satellite-independent layers, being in compliance with the ETSI-BSM-QoS standards. The architecture is set up inside the gateway, it includes a Re-Queuing Mechanism (RQM) to enhance the goodput of the EF and AF traffic classes and an adaptive IP scheduler to guarantee the high-priority traffic classes taking into account the channel conditions affected by rain events. One of the most important aspect of the architecture design is that QoSatAr is able to guarantee the QoS requirements for specific traffic flows considering a single parameter: the bandwidth availability which is set at the physical layer (considering adaptive code and modulation adaptation) and sent to the network layer by means of a cross-layer optimization. The architecture has been evaluated using the NS-2 simulator. In this article, we present evaluation metrics, extensive simulations results and conclusions about the performance of the proposed QoSatAr when it is evaluated over a DVB-S2 satellite scenario. The key results show that the implementation of this architecture enables to keep control of the satellite system load while guaranteeing the QoS levels for the high-priority traffic classes even when bandwidth variations due to rain events are experienced. Moreover, using the RQM mechanism the user’s quality of experience is improved while keeping lower delay and jitter values for the high-priority traffic classes. In particular, the AF goodput is enhanced around 33% over the drop tail scheme (on average)

Vitamin d and the risk of non-melanoma skin cancer: A systematic literature review and meta-analysis on behalf of the italian melanoma intergroup

We aimed to provide a comprehensive overview of the link between vitamin D and non-melanoma skin cancer (NMSC). For this purpose, we conducted a systematic literature review (updated to 3 February 2021) and meta-analysis of the studies reporting on the association between vitamin D intake (from diet and supplements) and blood concentration, polymorphisms of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes, and the risk of NMSC. Random effects meta-analysis models were fitted to merge study-specific risk estimates into summary relative risk (SRR) and corresponding 95% confidence intervals (CI). Twenty-four studies altogether were included. There was a suggestive association between increasing serum/plasma vitamin D concentration and NMSC risk (SRR for highest vs. lowest concentration 1.67, 95%CI 0.61–4.56), although with large heterogeneity across studies (I2 = 91%). NMSC risk was associated with highest vitamin D intake in observational studies but not in clinical trials. Finally, there was no significant association between any polymorphism of the VDR and VDBP genes and NMSC risk. In conclusion, no strong relationship between vitamin D metabolism and NMSC risk appears to exist according to our systematic review and meta-analysis, although some findings are worthy of further investigation

Exogenous sex hormones, menstrual and reproductive history, and risk of non-melanoma skin cancer among women: a systematic literature review and meta-analysis

Non-melanoma skin cancers (NMSC) are more frequent among men, but women (especially those aged < 40 years) have experienced steeper growth in their incidence rates in recent years. Hormonal factors were hypothesized to be playing a role in modulating NMSC risk, but the studies published to date provided conflicting results. We systematically reviewed and meta-analysed the studies focusing on the association between hormone-related characteristics (use of exogenous sex hormones, and aspects of menstrual and reproductive history) and the risk of NMSC among women. We included observational and experimental studies published in PubMed and EMBASE until February 2020. We calculated summary relative risk (SRR) and 95% confidence intervals (CI) by applying random effects models with maximum likelihood estimation, and used the I2 statistics to quantify the degree of heterogeneity of risk estimates across studies. Eleven independent studies encompassing a total of over 30,000 NMSC cases were included in quantitative analyses. No evidence of an increased NMSC risk emerged among ever vs. never users of oral contraceptives (SRR 1.13, 95% CI 0.88–1.45) or hormones for menopause (SRR 1.09, 95% CI 0.87–1.37). Likewise, age at menarche or at menopause and parity were not associated with NMSC risk. Heterogeneity across studies was low, and pooled results were comparable between NMSC subtypes. We found no evidence that hormonal factors play a role in the pathogenesis of NMSC among women